Место работы автора, адрес/электронная почта: Российская медицинская академия непрерывного профессионального образования, Иркутская государственная медицинская академия последипломного образования ; 664049, г. Иркутск, мкр-н Юбилейный, 100 ; e-mail: olff@mail.ru ; https://igmapo.ru
Ученая степень, ученое звание: канд. мед. наук
Область научных интересов: Медицина и здравоохранение
ID Автора: SPIN-код: 5380-4524, РИНЦ AuthorID: 637294
Количество страниц: 6 с.
The possibility of slowing down vascular remodeling in hypertensive patients with the combined effect of antihypertensive drugs and statins has been studied in few works. The effect of spironolactone on vascular stiffness in relation to the severity of the hypotensive effect in combination therapy has also been insufficiently studied. The aim of the research was to study the dynamics vascular stiffness parameters in hypertension patients of high/very high cardiovascular risk in addition rosuvastatin or spironolactone to combined two-component amlodipine and lisinopril therapy. 90 patients with hypertension were randomized into groups: the first group received a fixed combination of amlodipine/lisinopril, the secons one followed the same regimen of therapy with addition of 20 mg rosuvastatin, the third - in addition to the combination of amlodipine / lisinopril received spironolactone. After 6 months of the therapy, office and average daily blood pressure decreased in all groups, to a greater extent in the group adding spironolactone to therapy. In the rosuvastatin group, a greater degree of decrease in office diastolic blood pressure was noted. The augmentation index significantly decreased in all groups, mainly in the statin supplementation group. In patients who received a fixed combination of amlodipine/lisinopril, only the speed of propagation of the pulse wave in the carotid-femoral decreased, and with the addition of spironolactone and rosuvastatin - and in the carotid-radial
Федоришина, О. В. Возможности коррекции сосудистой жесткости под влиянием статина и спиронолактона при артериальной гипертензии: промежуточные результаты проспективного исследования "артерия-АГ" / О. В. Федоришина, А. М. Торунова, К. В. Протасов // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2021. — N 1 (22). — С. 5-10.
DOI: 10.25587/SVFU.2021.22.1.001